中文名 | BAM15 |
英文名 | BAM15 |
别名 | 化合物BAM 15 N5,N6-双(2-氟苯基)-[1,2,5]恶二唑并[3,4-B]吡嗪-5,6-二胺 |
英文别名 | BAM15 CS-2890 N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine [1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine, N5,N6-bis(2-fluorophenyl)- BAM 15 (N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine) |
CAS | 210302-17-3 |
化学式 | C16H10F2N6O |
分子量 | 340.29 |
密度 | 1.548±0.06 g/cm3(Predicted) |
沸点 | 421.7±55.0 °C(Predicted) |
溶解度 | 溶于DMSO (35 mg/ml) |
酸度系数 | -2.40±0.50(Predicted) |
存储条件 | -20°C |
稳定性 | 从提供的购买之日起稳定2年。DMSO中的溶液可以在-20 °C下储存长达1个月。 |
外观 | 粉末 |
颜色 | white to beige |
体外研究 | BAM 15 is able to increase O 2 consumption across a broad dosing range without increasing ROS. BAM 15 and FCCP are structurally unrelated and it is observed that low doses of BAM 15 from 100 nM to 1 μM increase cellular O 2 consumption rate (OCR) to a similar degree as FCCP, but higher concentrations from 1 μM to 50 μM reveal that BAM 15 is able to maintain uncoupled respiration at a high rate in a range of cell lines. BAM 15 is fully capable of increasing mitochondrial respiration in the presence of oligomycin and does so across a broader concentration range than FCCP in both myoblasts and hepatocytes. BAM 15 induces mitochondrial swelling, demonstrating that BAM 15 is a protonophore. BAM15-treated cells are more viable than FCCP-treated cells when administered across a broad dosing range up to 50 μM. |
体内研究 | Compare to vehicle-treated mice, animals that receive BAM 15 are protected from kidney injury as indicated by lower plasma creatinine levels at 24 and 48 h post-ischemia, reduced tubular necrosis, less depletion of brush border villi, less obstruction of proximal tubules, and less immune cell infiltration. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.939 ml | 14.693 ml | 29.387 ml |
5 mM | 0.588 ml | 2.939 ml | 5.877 ml |
10 mM | 0.294 ml | 1.469 ml | 2.939 ml |
5 mM | 0.059 ml | 0.294 ml | 0.588 ml |
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